Testosterone Education Center

Testosterone therapy (TRT): clinical evidence vs. real-world experience
TRT is used for symptomatic, lab-confirmed low testosterone. Clinical trials show modest but meaningful improvements in sexual function and mood for many men, increases in lean mass and strength, correction of some forms of anemia, and gains in bone density (fracture reduction evidence is mixed). Large safety data suggest cardiovascular risk is not increased when therapy is appropriately prescribed and monitored. As with any hormone therapy, individualized dosing and regular labs (hematocrit, lipids, PSA as appropriate) are essential. Note that exogenous testosterone can suppress sperm production—use alternatives if you’re trying to conceive.

Beyond trials, there’s a wide range of real-world reports—some men describe better energy, focus, and libido within weeks, while others need dose/formulation adjustments to feel their best. Responses vary by baseline health, delivery method (gel vs. injections), and adherence.

Want to go deeper? Click the FAQ items and Clinical Studies buttons below to explore the evidence, safety considerations, and practical tips so you can make an informed decision.