NAD + Deep Dive
NAD+ clinical evidence vs. real-world experience
Human studies show that NAD-raising supplements (like NR/NMN) reliably increase NAD+ levels, with some early signals for specific outcomes (e.g., insulin sensitivity in select groups, walking performance in peripheral artery disease, and exploratory changes in blood pressure/arterial stiffness). Other trials are neutral, and rigorous data for IV or injection protocols are still limited—so results can vary.
That said, there’s a large body of anecdotal reports from real users describing better daytime energy, mental clarity, sleep quality, and workout recovery. While anecdotes aren’t the same as randomized trials, they offer helpful real-world context and can guide individualized plans. If you’re considering NAD+, we’ll tailor dosing and monitor response to see what works best for you
Does supplementation raise NAD+ in humans?
View RCT (Nature Communications, 2018) View Trial (npj Aging Mech Dis, 2017)
Cardiometabolic signals (blood pressure & arterial stiffness)
View RCT (Nature Communications, 2018)
Walking performance in Peripheral Artery Disease (PAD)
View RCT (Nature Communications, 2024)
Insulin sensitivity (NMN in prediabetic women)
View RCT (Science, 2021) Free full text (PMC)
Null or mixed results to know about
Summary of RCT (AJCN 2018) in review
Exercise & performance data
Older adults crossover (Eur J Nutr, 2020) No effect on endurance responses (bioRxiv, 2020)
What about IV NAD+?
Pilot (preprint, 2024) Narrative review (SUD/withdrawal), 2022
How strong is the research overall?
That said, there’s a large body of anecdotal reports describing perceived benefits (energy, focus, sleep)—useful for hypothesis-building, but not a substitute for medical advice or randomized trials.
Anecdotes: Energy & focus improvements
Read thread (NR energy/focus) Read thread (NMN energy) Read thread (NAD+ injections)
Anecdotes: Sleep & mood changes (mixed)
Read thread (fatigue after NAD+) Read thread (tolerance/waning effect)
Anecdotes: Gym/Performance
Read thread (NR+NMN & workouts) Read thread (energy/performance)
Anecdotes: IV vs Subcutaneous vs Oral
Read thread (IV NAD+) Read thread (SC vs IV)
Anecdotes: Skepticism / No benefit
Read thread (NR debate) Read thread (NR concerns)